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KMID : 0369819810110010106
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Jorunal of Korean Pharmaceutical Sciences
1981 Volume.11 No. 1 p.106 ~ p.114
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Effect of Manufacturing Methods on Content Uniformity of Tablets
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이민화/Lee MH
최후균/김길수/Choi HK/Kim KS
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Abstract
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Safety, efficacy and reliability are the three basic criteria that define the quality of any well-designed pharmaceutical dosage form. Content uniformity directly bears on each of the three criteria defining the quality of drug product. Effect of manufacturing methods and physicochemical properties of the drug on content uniformity of tablets was investigated. Chlorpheniramine maleate and micronized salicylic acid were used as main ingredients. Three different methods for incorporation of main ingredients with diluents were solvent mixing method, geometric dilution method, and simple mixing method. The solvent mixing method was the best one of the three.
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KEYWORD
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